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Neuropathic Pain: For patients with nerve-based pain, including conditions like peripheral neuropathy or chemotherapy-induced peripheral neuropathy, peptides that target nerve repair pathways show remarkable potential without the dependency risks of opioids

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However, similar to GnRH agonist, GnRH antagonist is associated with hypoestrogenic adverse effects, which require the addition of estradiol and norethindrone acetate (add-back therapy) to attenuate the hypoestrogenic effect (Schlaff et al., 2020)

The BAG2 functions as a molecular cochaperone interacting with the heat shock protein 70 family molecular chaperones (Hsp70/Hsc70) 61 while CANX functions as a molecular chaperone 62 , and both contribute to efficient protein folding 61,62

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