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Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)
This, in turn, is associated with side effects such as the appearance of dyskinesias
Dieses krpereigene Tripeptid aus Glutamin, Glycin und Cystein spielt eine zentrale Rolle beim zellulren Schutz vor oxidativem Stress
Quercetin increase the chemosensitivity of breast cancer cells to doxorubicin via PTEN/akt pathway
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