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In turn, this may contribute to the development of depression by increasing oxidative stress, DNA damage, and cell death in the body ( A 2020 study with 132 children and teens, 89 with and 43 without depression, found that the participants with depression had lower B12 levels and higher levels of homocysteine compared with those without depression ( In addition to depressive symptoms, low or deficient B12 levels may lead to other mental conditions, including psychosis and mood disorders ( Because a deficiency in B12 negatively impacts the central nervous system, people with low or deficient B12 levels may feel foggy-headed and have difficulty concentrating and completing tasks ( Fortunately, studies show that mental impairment related to low B12 levels can improve with B12 treatment
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The substance has attracted considerable attention on account of its multifarious pharmacological activities, which encompass antioxidant, anti-inflammatory, anti-fibrotic, anti-apoptotic, and anti-tumor effects, as well as cardioprotective properties ( in vitro and in vivo studies have demonstrated promising protective effects ( Significant efforts have notably been invested in developing novel drug delivery systems (DDS) and device-assisted administration strategies to enhance the targeting, solubility and bioavailability of Tan IIA, thereby achieving more efficient cardioprotection ( 2 Drug delivery systems and device-assisted administration systems for Tanshinone IIA 2.1 Drug delivery systems A drug delivery system (DDS) can be defined as a device or method that efficiently transports a therapeutic agent to its target site, with the aim of optimizing the drug's absorption, distribution, metabolism, and excretion (ADME) profile
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