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Also, addition of BSO only very slightly reduced the GSH level in the ASG-10 cells, and no effects were observed at the levels of ROS and cell death

In hepatic insulin resistance, normal tyrosine phosphorylation of IR and IRS is compromised, diminishing PI3K activity associated with IRS

The complex mechanisms involved need to be elucidated further to help us better modulate the degree of ferroptosis caused by drugs or gene regulation for the treatment of diseases

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