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If low homocysteine is from CBS upregulation: If you have CBS gene mutations causing rapid conversion of homocysteine to cysteine, adding methylated B vitamins may further lower homocysteine without addressing the underlying issue

TGR was also identified as a multifunctional oxidoreductase with a remarkably wide substrate specificity, capable of directly reducing peroxides, selenium-containing compounds, and several important low-molecular-weight antioxidants, as well as Trx, DTNB, GSSG, and GSH-HED

doi: 10.1002/adfm.202011171 61 DogheimGMEl FeelNEAbd El-MaksodEAAmerSSEl-GizawySAAbd ElhamidASet al

10.1542/peds.2008-2445 21

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