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This process of telomere shortening is widely recognized as one of the most fundamental drivers of biological aging

Conversely, medications like metformin, H2 blockers, and proton pump inhibitors can reduce the absorption of Vitamin B12

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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If you are on medication or a supplement regimen for any other health condition