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In clinical trials, it demonstrated an 86 percent reduction in vertebral fractures compared to placebo, with greater bone mineral density increases than teriparatide at all measured skeletal sites

With proper standardization and dosing, many natural metabolites appear to cause fewer severe side effects than some synthetic drugs (though vigilance is still required, as any bioactive substance can pose risks at high doses or in susceptible individuals)

PDRN (polydeoxyribonucleotide) is the most commonly recommended gentler alternative to copper peptides

16 CheF.WangG.YuJ.WangX.LuY.FuQ.et al (2017)