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IL-1 is known to directly induce fatigue and malaise through stimulating the hypothalamic-pituitary-adrenal axis and inflammatory signaling pathways in the central nervous system (CNS) [35, 36]

Biomolecules 10 , 358, (2020)

Research includes evaluation of: .Reactive oxygen species (ROS) .Superoxide dismutase activity .Cellular antioxidant systems .Oxidative biomarkers These investigations contribute to broader understanding of cellular aging and biological maintenance

1 Introduction The immune response against pathogens and non-pathogens is regulated by key signaling pathways

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