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The genius of the LR3 modificationsubstituting an Arginine for a Glutamic Acid at the third position and adding a 13 amino acid extension peptideis that it dramatically reduces its affinity for these binding proteins

However, as reviewed elsewhere multiple studies determining the differences in proteomes between -thalassemia/HbE patients and healthy volunteers rarely identify common proteins as a consequence of the usage of different samples sources (erythrocytes, platelet free plasma derived microparticles, plasma, etc) and different analysis methodologies, as extensively reviewed elsewhere 20

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