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demonstrated that monocyte involvement contributes to AVF remodeling and stenosis through a monocyte depletion experiment ( Molecular mechanism of arteriovenous fistula failure Arteriovenous fistula have been recommended as the first choice for HD by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative on account of the superior long-term patency rates, fewer complications, and lower financial burden (5658)

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An exciting possibility would be to generate human-induced pluripotent stem cell (hiPSC)-derived organoids [530,531] in a gutbrain axis chip [523,524] to study the proposed interactions