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These coefficients are provided in Supplementary Data 10

J Matern Fetal Neonatal Med

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HIF-1a is known to be involved in cellular responses to hypoxia and oxidative stress

found that induction of haem oxygenase-1 through activation of the Nrf2-ARE pathway protected melanocytes from H 2 O-induced toxicity and that upregulation of Nrf2 expression reduced H 2 O 2 -induced apoptosis of human melanocytes [27]