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Insulin-like growth factor 1 (IGF-1) plays a critical role in regulating the hair cycle, including controlling hair shaft differentiation and tissue remodeling, and serving as a key regulator of mitogenic and morphogenetic processes during hair follicle development[13,14]

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GLP-1 receptor agonists, including tirzepatide, reduce hepatic fat accumulation

This implies that diminished citrate levels may signal aberrant glucose metabolism and elevated diabetes risk

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