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86,87,88,89 To prevent lactate accumulation from leading to lactic acidosis, pyruvate dehydrogenase (PDH) catalyzes the production of acetyl coenzyme A from pyruvate, which joins the TCA cycle and irreversibly removes lactate

[DOI] [PMC free article] [PubMed] [Google Scholar] Schalkwijk CG, Stehouwer CDA (2020) Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases

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