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The lack of sufficient glutathione in the reduced state relative to the oxidized state may be due to lack of production of glutathione (reduced) or an excess of the materials such as toxins that consume glutathione (reduced)
Storage alters proteolysis in RBCs Storage lesion, a gradual degradation of RBCs during hypothermic storage, reduces their function and post-transfusion circulatory lifespan 9
doi: 10.3390/ijms22115512 81