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They classified p53 mutations into two groups: disruptive mutations which can lead to the LOF of the mutant p53 proteins, and non-disruptive mutations which partially retain some functions of WT p53 and are reportedly often associated with DNE and alleged GOF effects of mutant p53 [166]

They still do deliver nicotine, but without burning tobacco, which is what produces the toxins in regular smoke

University of Michigan: Survey Research Center 2016

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