These can cause differences in the conformation of the heavy chains of antibodies, with resultant changes in antibody binding affinity and activation of the complement system
[6] As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1GLV, PDB: 1GSA, PDB: 1GSH, PDB: 1M0T, PDB: 1M0W, PDB: 2GLT, and PDB: 2HGS
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The latter then donates an amino group to an alpha-keto acid, alpha-ketoglutarate, to form an amino acidpyridoxal 5-phosphate Schiffs base intermediate that is then reduced to form glutamate
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