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This interorganelle distribution suggests that mitochondrial CoQ 10 oxidoreductases, such as DHODH, may influence ferroptosis beyond mitochondria by maintaining the redox state of CoQ 10 pools across multiple cellular membranes

This difference has significant implications for both short-term effects and long-term outcomes

Label reconstituted samples clearly with preparation date and concentration

Glutathione has essential intracellular roles in yeast, so the gsh1 -mutant can only grow in media that we supplement with glutathione 40

Thioredoxin can react with ROS and compensate for reduced GSH levels to maintain a reduced state of proteins [51, 52]