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ETHICAL APPROVAL AND INFORMED CONSENT Ethical approval and informed consent were not required for this study which was a secondary analysis of existing data

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Body temperature and locomotion following acute and repeated electronic nicotine vapor exposure After identifying the metabolic, molecular, and cellular changes following acute and repeated electronic nicotine vapor exposure, we examined the in vivo impact of electronic nicotine vapor after a single acute session, after repeated 5-d sessions, or 72 h after the final session of the repeated sessions (withdrawal)

Therefore, it seems that host factors, the dose of nicotine, and comorbidities determine the harmful or the protective effect of nicotine