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In addition, users frequently co-administer other substances intended to enhance performance or physique, including growth hormone, thyroid hormones, and insulin, further complicating prevalence estimates and risk assessment ( A large meta-analysis by Sagoe et al., encompassing 271 studies, estimated the average lifetime prevalence of androgen use to be 6.4% among men and 1.6% among women

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Vitamin E protects rat mesenchymal stem cells against hydrogen peroxide-induced oxidative stress in vitro and improves their therapeutic potential in surgically-induced rat model of osteoarthritis