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Another potential therapeutic, Minocycline is a microglial inhibitor which reduces BBB dysfunction by preventing production of glutamate, matrix metalloproteinases, and the proinflammatory cytokine, IL-1, and increasing the levels of cells responsible for the remyelination of neurons which would be relevant in treating AD [138, 140,141,142]

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If youre considering adding coffee enemas into a broader detox or gut-healing plan, working with a qualified functional medicine provider ensures youre doing it safely and effectively.These individuals should not perform coffee enemas: Those with inflammatory bowel disease (Crohns, UC) Severe hemorrhoids Kidney disease Heart rhythm disorders Pregnant individuals Those sensitive to caffeine Consult a licensed medical provider before starting any detox or gastrointestinal protocol

Cells 8:246

June 20, 2025