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In a clinical study involving patients with refractory SLEdefined as those with persistent disease activity despite high-dose glucocorticoids and/or cytotoxic drugsthe combination of Low-dose IL-2 (100 WIU, 35 days/month) and rapamycin(0.5 mg every other day) demonstrated synergistic effects (272)

It is currently being investigated in a phase III, multi-center, double-blind, randomized clinical trial for TBI (Cekic and Stein, 2010)

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Individuals who suffer from multiple morbidities and are exposed to numerous therapeutic agents may be at an increased risk of developing hypersensitivity to haptens