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Chruszcz, M

Incubation of isolated rat liver mitochondria with ADP/Fe 3+ /Asc resulted in substantial protein oxidation (measured by protein carbonylation) and an increase in the amount of 8-hydroxy-2-deoxyguanosine (8-OHdG), a product of oxidative damage to DNA

Furthermore, IL-6 secretion induced by platinum-based chemotherapy promotes cancer stem cell (CSC) enrichment in high-grade serous carcinoma (HGSC), facilitating CSC expansion from dormant senescent cells, a crucial driver of tumor recurrence (Wang et al., 2018)

Shiromizu, C

This approval was based on the STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program, which enrolled over 4,500 participants