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Similar content being viewed by others Main Dopamine (DA) signalling in the striatum, a key integrator of cortical and thalamic information and a significant target of midbrain DA (mDA) neurons from the substantia nigra pars compacta (SNc) 1 , has an essential role in a wide range of behaviours, including control of voluntary motor movements, procedural learning, habit learning and cognition 1,2

This synergy operates through multiple mechanisms [7] : The REDEFINE 1 trial demonstrated that CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) produced 15.6% weight loss compared to 10.8% with cagrilintide alone and historical data of ~15% with semaglutide alone, suggesting true synergy [7]

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