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However, observational studies cannot exclude the possibility that elevated homocysteine levels may be associated with confounding variables such as unhealthy lifestyles and other established risk factors, rather than being causally related to vascular disease

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Omland T, Samuelsson A, Hartford M, Herlitz J, Karlsson T, Christensen B, and Caidahl K (2000)

The completion of GSH synthesis is catalyzed by glutathione synthetase (GS), in a reaction in which -glutamyl-cysteine is covalently linked to glycine ( Figure 1 )

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