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First discovered in human plasma in the early 1970s, this molecule has since gained attention for its regulatory role in numerous biological pathways related to repair, regeneration, and protection

Because they target the brains reward centre, the mesolimbic system, they apparently do not just stop food noise but inadvertently the quiet joy found elsewhere

A 2025 human pilot study reported no adverse cardiac, hepatic, or renal effects at IV doses of 10-20mg

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