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Because of the broad expression of these nAChRs, nicotine exerts broad effects on the nervous system that likely underlie its high degree of co-morbidity with other neuropsychiatric disorders

Rosen posited the theory to his colleague Cande Ananth, the medical schools chief of the Division of Epidemiology and Biostatistics in the Department of Obstetrics, Gynecology, and Reproductive Sciences, who had both the relevant data and the analytic skills to help test it

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