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24 Cardiovascular effects Incretin analogues increase heart rate by about two to three beats per minute via indirect stimulation of sinoatrial nodal tissue through increased sympathetic nervous system activation

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doi: 10.1016/j.celrep.2015.04.013 32 GulN.AhmadP.WaniT

The role of CB839 in the tumor immune microenvironment has been extensively evaluated in preclinical experiments, revealing its distinct effects within the TME