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In 1972 Juregui-Adell et al

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It has been well established that Abeta, when incubated with copper and oxygen, produces H 2 O 2 , while reducing Cu 2+ to Cu 1+ , during the period when it slowly transforms into soluble oligomers ( 2 O 2 , levels decrease, suggesting that the fibrils that are ultimately formed may clear the H 2 O 2

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