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Ozkan, B., Orhan, E., Aktas, N

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The recent phase 2, placebo-controlled PANORAMA trial was designed to assess the safety and tolerability of NAC combined with pirfenidone in patients with IPF (n = 123) [32]

246 However, p38MAPK inhibitors block the upstream MAPK kinase kinases, leading to hyperactivation of the transforming growth factor-activated kinase-1 and mixed-lineage kinase which then hyperactivate the JNK