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N., van Velzen, M., et al

San Antonio, TX: Psychological Corporation

Its levels decrease as a result of aging, stress and exposure to toxins

The primary reason for this is that, while androgen precursors are activated in peripheral target tissues, this is often, but not always, followed by subsequent inactivation within the same tissue, thus with the result that much of the active androgen is never accounted for in circulation (Section 2.5.3.2)

Targeting ETC CI enhances 5FU response and extends survival The ultimate goal of better understanding mechanisms promoting 5FU tolerance is to allow us to design rational treatment combinations that are more effective than the current standard of care