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Concurrently, TGF-1-mediated fibrous encapsulation drives joint structural remodeling and cartilage degradation ( 2.2 Pathogenesis and pathophysiology of hyperuricemia Hyperuricemia is the precursor state to gout, but its pathophysiological impact extends far beyond the joints, involving multiple systems, including cardiovascular diseases, chronic kidney disease, and metabolic disorders (Figure 2

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TABLE 2 Representative phytochemicals that regulate mitochondrial quality control in endometriosis

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