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Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology

Signs include feeling heavy or tired, dry mouth, irritability, or feeling "toxic" or not quite right

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For the ACC, a VOI with a size of 30 30 20 mm 3 was aligned with the corpus callosum shape and positioned superior and posterior to the genu of the corpus callosum