Similar content being viewed by others Background l-glutathione (-glutamyl-l-cysteinylglycine, GSH) is a tripeptide that is the most abundant non-protein thiol in animals, plants, and microorganisms [1]
These findings suggest that microglia mediate, at least partially through the SLC7A11ALOX12 axis, the beneficial effects of exercise in suppressing ferroptosis (Xu J
A latest study has shown that the overexpression of the LA synthase gene (Lias) significantly attenuated oxidative stress (Tfam) and histological steatosis in the livers of db/dbC57BL/6 mice fed a normal diet [87]
In the liver, a major site of GSH metabolism, this consists of: a) extensive catabolism of GSH within biliary spaces (Ballatori et al., 1986b, 1988, 1989), as well as within sinusoidal compartments of some species (Hinchman and Ballatori, 1990, 1994), b) direct hepatic reabsorption of some of the breakdown products (Ballatori et al., 1986a, 1988
The precipitate was collected and redissolved in deionized water
