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Morphologically, it is mainly manifested as ultrastructural changes of mitochondria, such as shrinkage of mitochondria, increased density of mitochondrial membrane, and rupture of mitochondrial cristae and outer membrane

Wang X, Mak PY, Mu H, Jian X, Mak D, Pachter JA, Weaver DT, XU B, Andreeff M , Carter BZ

In fact, neuroinflammation is now considered a predisposing risk factor for learning and memory impairment [21], and elevated neuroinflammation and oxidative stress, driven by increased microglial activation, are linked to age-related cognitive decline [130]

Heavy metal toxicity may damage: central nervous system cardiovascular system gastrointestinal system lungs kidneys liver endocrine glands bones Fortunately, integrative interventions like selenium and garlic have been shown to decrease the buildup and increase the excretion of toxic heavy metals