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doi: 10.1111/jpi.12730 51 ZhangCCloughSJAdamah-BiassiEBSveinssonMHHutchinsonAJMiuraIet al

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The natural pathogenesis of HIV consists of three stages: 1) the primary HIV infection phase, 2) the asymptomatic chronic phase, and 3) the late HIV symptomatic phase, which leads to an immunocompromised state resulting in increased susceptibility to opportunistic infections