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In chemically induced ulcer and colitis models, it supported mucosal integrity and reduced histological signs of inflammation [4]

The mechanism underlying these opposing gastrointestinal effects likely relates to semaglutides complex effects on gastrointestinal motility, with some patients experiencing accelerated intestinal transit while others experience overall slowing of gastrointestinal motility

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Also, people who have had surgery on their intestines, like weight loss surgery, or have diseases that affect the gut, like Crohns disease or celiac disease, are also at risk of not getting enough vitamin B12