This is a genuinely difficult question to answer with intellectual honesty
Meanwhile, the broader senolytic field has advanced dasatinib+quercetin has completed multiple human trials including Phase 2 in Nature Medicine (Farr 2024)
proved, through an in vivo study with model rats and an in vitro study using organotypic hippocampal slice cultures, that nicotinamide mononucleotide improved learning and memory in Alzheimers disease rats while also reducing the accumulation of ROS and cell death in organotypic hippocampal slice cultures
A physician investigating unexplained hypercobalaminemia will typically order some combination of the following: Complete blood count (CBC) with differential to check for abnormal red blood cell, white blood cell, or platelet counts Liver function tests (ALT, AST, ALP, bilirubin, albumin) to assess liver health Kidney function tests (creatinine, BUN, estimated GFR) to evaluate renal clearance Peripheral blood smear if a myeloproliferative disorder is suspected Abdominal imaging (ultrasound or CT) if liver or abdominal pathology is a concern Cancer-specific markers or screenings if clinical suspicion warrants them The NIH Office of Dietary Supplements fact sheet notes that observational data from a Danish registry analysis of 757,185 people found the adjusted 1-year cancer risk was 1.74 to 4.72 times higher among those with B12 above 813 pg/mL compared to those in the normal range of 203 to 813 pg/mL
Ordinary early drowsiness is usually monitored
