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2.1 The antagonistic relationship between Th17/Treg during differentiation pathways 2.1.1 Transcription factor regulation A vital mechanism in the control of immunological homeostasis is the mutual antagonistic relationship between RORt and Foxp3 ( Figure 1 ), which is a crucial intrinsic factor affecting the differentiation pathways of Th17 and Treg cells

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282 Further studies by the Encyclopedia of DNA Elements (ENCODE) project indicated that up to 80% of the human genome, including coding DNA, can undergo transcription, suggesting the presence of a substantial amount of non-coding RNA in the human body

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