Finally, noncerebellar symptoms have been also evaluated in the natural history of SCA3 and should be reported thoroughly, as these can also be extremely debilitating for patients [255]
While the transcriptional mechanisms controlling gene expression by ROS are not fully understood, they partially rely on nuclear ROS translocation from the cytosol and organelles, activation and redox modifications of transcription factors and chromatin remodeling proteins (Dietz, 2014
In such cases, targeted radiological imaging, such as magnetic resonance imaging (MRI) 49 or computed tomography (CT), 50 is essential to identify underlying structural or vascular causes
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