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When mitochondria cannot increase energy output efficiently, cells may depend more heavily on creatine and phosphocreatine buffering

It binds to ghrelin receptors in the hypothalamus and pituitary gland, stimulating a powerful GH pulse

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Curr Med Chem 2018;25:157795

Despite promising therapeutic effects, challenges remain in probiotic application for MAFLD, such as the strain-specific nature of probiotics, host genetic and microbiota variability, and concerns regarding long-term safety and regulatory standardization