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Chronic oxidative stress can also deplete cellular glutathione

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[1-13C]Glucose entry in neuronal and astrocytic intermediary metabolism of aged rats

We also determined thiol levels in the PfK13 knocksideways line in the presence of RAP and found that mislocalisation of PfK13 significantly elevated levels of reduced GSH and its precursor gGlu-Cys (Fig 4D)