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Others found a ketogenic diet increased the total NAD + /NADH in the hippocampus, but not in the frontal cortex, of male Sprague Dawley rats ( + ]/[NADH] induced by ketone ester treatment and the oxidizing shift in the total NAD + /NADH during a ketogenic diet were opposite to the reductive shifts that occurred in the hippocampus and cortex during fasting, as discussed above

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Sullivan 2009)

The FDX1-mediated process culminates in profound proteotoxic stress driven by the aggregation of lipoylated mitochondrial proteins and the concomitant destabilization of Fe-S cluster proteins, which together lead to acute mitochondrial failure [3]