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Based on these limitations, future research should integrate detailed exposure metrics, genetic profiling, and chronotype assessments to better clarify mechanisms and identify high-risk subgroups

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Semaglutide (CagriSema) The most extensively studied cagrilintide combination pairs it with semaglutide: The CagriSema combination demonstrates that adding amylin pathway activation to GLP-1 agonism produces substantially greater weight loss than GLP-1 therapy alone[9]