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That is three problems converging into one miserable condition

2.10.1 Limitation of in-vitro model Despite their value in mechanistic research, in vitro models present several critical limitations that constrain their translational applicability (Blanchard et al., 2022)

Its well-characterized molecular structure and stable composition have made it a widely referenced material in peptide and antioxidant chemistry research

Gastroenterology 120 , 411422 (2001)