More serious B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes
If used in these patients, more frequent monitoring is required because of the potential for erratic or blunted absorption
Rotate injection sites (abdomen, thighs, upper arms) to minimize local irritation
Q9: Does it increase metabolism
A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss