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The rostral two burr holes were placed just basal from the posterior interocular line, the basal two burr holes were placed just rostral to the lambdoid suture (and transverse sinuses) on both sides, respectively, and the middle two burr holes were placed in the line between the basal and rostral burr holes

For brain applications specifically, the gut-brain axis connection is significant

Propulsive peristaltic waves in the colon are decreased, while tone may be increased to the point of spasm, resulting in constipation

10.1017/s0967199418000485 165 SinghA.KukretiR.SasoL.KukretiS