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unmodified form Distribution and Elimination: Plasma half-life comparison to standard Epitalon (hypothesis: extended) Tissue distribution patterns under investigation Metabolic stability assessment in plasma and tissue homogenates Renal clearance characteristics Cellular uptake and retention studies Biological Activity Timeline: Comparative time-course studies with Epitalon Assessment of sustained vs

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Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, Dalerba P, et al

Peptide-induced locomotor activity in SD, WKY and SHR rats Animals were placed in open-field chambers for 30 min daily on two to three consecutive days, constituting their baseline locomotor activities