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103 In one randomized clinical trial in 70 volunteers with chronic tinnitus, both 3 mg of melatonin daily and a standard dose of sertraline (Zoloft) (an antidepressant medication) for three months reduced tinnitus severity, but melatonin was more effective

The importance of determining proper dosing strategies is highlighted by animal research that suggests, for example, that while LDN may suppress tumors when used in the typical fashion, it may actually enhance tumor growth when administered more frequently [48]