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sapiens GRCh38 reference genome was used for mapping RNA-seq reads

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Boolean operators and Medical Subject Headings (MeSH) were applied to refine the search strategy

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When to Be Concerned In a research context, further evaluation may be warranted if observations include: Rapidly expanding redness beyond the injection site Severe or escalating pain Persistent swelling lasting multiple days Signs of infection (increasing warmth, spreading redness, discharge) Systemic symptoms such as generalized hives, shortness of breath, dizziness, or facial swelling Severe or systemic reactions should be treated as medically significant and require appropriate clinical evaluation