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Potential users should be aware that while preclinical safety appears excellent, the absence of extensive human clinical trials means unknown risks may exist

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Insofar we did not evaluate the direct interaction of GSB-106 with TrkB, as well as with p75 NTR , the role that distinct receptor plays in pro-survival properties of GSB-106 couldn't be precisely resolved and requires further detailed investigations

Research results suggest that a diet rich in polyphenols reduces the risk of intestinal barrier dysfunction [8, 150]